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  ONCOTREX
 Manufacturer Inca (Sun)
 Generic Methotrexate
 Package/s Injection 50 mg, (Rs. 51.00)
  Tablet 2.5 mg, (Rs. 48.00)
 About Methotrexate Antimetabolite ,antifolate, Immunosuppressant, Antineoplastic, Antirheumatic. More details.....
 Dosage Oral- Adult- For acute lymphoblastic leukemia: 15mg/metre square once or twice weekly For choriocarcinoma: 15 to 30 mg/day for 5 days at intervals ....More details.....
 Pregnancy Contraindicated
 Breast Feeding Contraindicated
 Old Age Use with caution
 Children Use with caution
 Mechanism Of Action Drug inhibits the enzyme dihydrofolate reductase (DHFR), which catalyses the conversion of dihydrofolate to active tetrahydrofolate.It is an important....More details.....
 PharmacoKinetics Absorption-Absorption after oral administration depends upon the doses. At lower doses there is complete absorption and at larger doses incomplete abs....More details.....
 AdverseEffect 1. Nausea 2. Vomiting 3. Difficulty in breathing 4. Closing of the throat 5. Bone marrow suppression 6. Bruising or unusual bleeding 7. Tarry st....More details.....
 SpecialPrecautions 1. Renal impairment 2. Hepatic impairment 3. Bone marrow depression 4. Ulcerative disorders of the GIT 5. CNS disturbances 6. Folate deficiency ....More details.....
 Indications 1. Acute lymphoblastic leukemia 2. Choriocarcinoma 3. Burkitt`s lymphoma 4. Meningeal leukemia 5. Lymphosarcoma 6. Hydatidiform mole 7. Psoriasi....More details.....
 Interactions Aminoglycosides: Decrease absorption and AUC of oral methotrexate. Charcoal: Decreases serum level of both oral and IV methotrexate. Etretinate: He....More details.....
 Storage Stored at room temperature away from light and moisture....More details.....
 MissedDosage Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.....More details.....
 Overdose Give symptomatic and supportive treatment. Administer an antagonist (calcium leucoverin) for hematopoetic toxicity, within one hour after methotrexate intake.....More details.....
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Price comparison, Drug alerts (Pregnanacy, Breast Feeding, Old Age) and More details.....
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